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Beyond Malaria — Causes of Fever in Outpatient Tanzanian Children

Author: 

D Acremont, Valerie

Kilowoko, Mary

Kyungu, Esther

Philipina, Sister

Sangu, Willy

Kahama-Maro, Judith

Lengeler , Christian

Cherpillod , Pascal

Kaiser, Laurent

Genton, Blaise

Publication: 

New England Journal of Medicine

Page(s): 
809-817

As the incidence of malaria diminishes, a better understanding of nonmalarial fever is important for effective management of illness in children. In this study, we explored the spectrum of causes of fever in African children. Researchers recruited children younger than 10 years of age with a temperature of 38°C or higher at two outpatient clinics — one rural and one urban — in Tanzania. Medical histories were obtained and clinical examinations conducted by means of systematic procedures. Blood and nasopharyngeal specimens were collected to perform rapid diagnostic tests, serologic tests, culture, and molecular tests for potential pathogens causing acute fever. Final diagnoses were determined with the use of algorithms and a set of prespecified criteria.

Resource Type: 
Region: 
Country / Countries: 
Tanzania

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